Orengo, CA and Martin, AM and Hutchinson, G and Jones, S and Jones, DT and Michie, AD and Swindells, MB and Thornton, JM (1998) Classifying a protein in the CATH database of domain structures. ACTA CRYSTALLOGR D , 54 1155 - 1167.
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The CATH database of protein domain structures classifies structures according to their (C)lass, (A)rchitecture, (T)opology or fold and (H)omologous family (http://www.biochem.ucl.ac.uk/bsm/cath) Although the protocol used is mostly automatic, manual inspection is used to check assignments at some critical stages, such as the detection of very distantly related homologues and anologues and the assignment of novel architectures. Described in this article is a recently established facility to search the database with the coordinates of a newly determined structure. The CATH server first locates domain boundaries and then uses automatic sequence and structure comparison methods to assign this new structure to one or more of the domain families within CATH. Diagnostic reports are generated, together with multiple structural alignments for close relatives. The Server can be accessed over the World Wide Web (WWW) and mirror sites are planned to improve access.
|Title:||Classifying a protein in the CATH database of domain structures|
|Keywords:||STRUCTURE ALIGNMENT, SCHEMATIC DIAGRAMS, DATA-BANK, PROGRAM, SEQUENCE, CLASSIFICATION, GENERATION, HOMOLOGY, SEARCH|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology|
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
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