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DNA methylation markers for early detection of women's cancer: promise and challenges

Wittenberger, T; Sleigh, S; Reisel, D; Zikan, M; Wahl, B; Alunni-Fabbroni, M; Jones, A; ... Widschwendter, M; + view all (2014) DNA methylation markers for early detection of women's cancer: promise and challenges. Epigenomics , 6 (3) 311 - 327. 10.2217/epi.14.20. Green open access

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Abstract

Breast, ovarian and endometrial cancers cause significant morbidity and mortality. Despite the presence of existing screening, diagnostic and treatment modalities, they continue to pose considerable unsolved challenges. Overdiagnosis is a growing problem in breast cancer screening and neither screening nor early diagnosis of ovarian or endometrial cancer is currently possible. Moreover, treatment of the diversity of these cancers presenting in the clinic is not sufficiently personalized at present. Recent technological advances, including reduced representation bisulfite sequencing, methylation arrays, digital PCR, next-generation sequencing and advanced statistical data analysis, enable the analysis of methylation patterns in cell-free tumor DNA in serum/plasma. Ongoing work is bringing these methods together for the analysis of samples from large clinical trials, which have been collected well in advance of cancer diagnosis. These efforts pave the way for the development of a noninvasive method that would enable us to overcome existing challenges to personalized medicine.

Type: Article
Title: DNA methylation markers for early detection of women's cancer: promise and challenges
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/epi.14.20
Publisher version: http://dx.doi.org/10.2217/epi.14.20
Language: English
Additional information: © Martin Widschwendter et al. This work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-ncnd/3.0/
Keywords: DNA methylation, cancer, circulating cell-free DNA, digital PCR, epigenetics, methylation arrays, personalized medicine, plasma, reduced representation bisulfite sequencing, screening, serum
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Women's Cancer
URI: http://discovery.ucl.ac.uk/id/eprint/1449326
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