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Central Topography of Cranial Motor Nuclei Controlled by Differential Cadherin Expression

Astick, M; Tubby, KC; Mubarak, WM; Guthrie, SC; Price, SR; (2014) Central Topography of Cranial Motor Nuclei Controlled by Differential Cadherin Expression. Current Biology , 24 (21) 10.1016/j.cub.2014.08.067. Green open access

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Abstract

Neuronal nuclei are prominent, evolutionarily conserved features of vertebrate central nervous system (CNS) organization [1]. Nuclei are clusters of soma of functionally related neurons and are located in highly stereotyped positions. Establishment of this CNS topography is critical to neural circuit assembly. However, little is known of either the cellular or molecular mechanisms that drive nucleus formation during development, a process termed nucleogenesis [2-5]. Brainstem motor neurons, which contribute axons to distinct cranial nerves and whose functions are essential to vertebrate survival, are organised exclusively as nuclei. Cranial motor nuclei are composed of two main classes termed branchiomotor/ visceromotor and somatomotor [6]. Each of these classes innervate evolutionarily distinct structures, for example, the branchial arches and eyes respectively. Additionally, each class is generated by distinct progenitor cell populations and are defined by differential transcription factor expression [7, 8]; for example, Hb9 distinguishes somatomotor from branchiomotor neurons. We characterized the timecourse of cranial motornucleogenesis finding that despite differences in cellular origin, segregation of branchiomotor and somatomotor nuclei occurs actively, passing through a phase of each being intermingled. We also found that differential expression of cadherin cell adhesion family members uniquely defines each motor nucleus. We show that cadherin expression is critical to nucleogenesis as its perturbation degrades nucleus topography predictably.

Type: Article
Title: Central Topography of Cranial Motor Nuclei Controlled by Differential Cadherin Expression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2014.08.067
Publisher version: http://dx.doi.org/10.1016/j.cub.2014.08.067
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1447949
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