UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart Failure.

Maestrini, V; Treibel, TA; White, SK; Fontana, M; Moon, JC; (2014) T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart Failure. Curr Cardiovasc Imaging Rep , 7 , Article 9287. 10.1007/s12410-014-9287-8. Green open access

[img]
Preview
PDF
art_10.1007_s12410-014-9287-8.pdf

Download (3MB)

Abstract

Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.

Type: Article
Title: T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart Failure.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s12410-014-9287-8
Publisher version: http://dx.doi.org/10.1007/s12410-014-9287-8
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Cardiac remodelling, Diffuse fibrosis, Extracellular space, Extracellular volume fraction, Heart failure, Interstitium, Intracellular space, Myocardial intracellular volume, Myocytes, T1 mapping
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: http://discovery.ucl.ac.uk/id/eprint/1447551
Downloads since deposit
109Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item