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LAMOTRIGINE-INDUCED CARBAMAZEPINE TOXICITY - AN INTERACTION WITH CARBAMAZEPINE-10,11-EPOXIDE

WARNER, T; PATSALOS, PN; PREVETT, M; ELYAS, AA; DUNCAN, JS; (1992) LAMOTRIGINE-INDUCED CARBAMAZEPINE TOXICITY - AN INTERACTION WITH CARBAMAZEPINE-10,11-EPOXIDE. EPILEPSY RES , 11 (2) 147 - 150.

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Abstract

We report an interaction between lamotrigine (LTG), a new antiepileptic drug (AED), and carbamazepine (CBZ) and its primary metabolite CBZ-10,11-epoxide (CBZ-E) in 9 consecutive patients (5 male, 4 female, aged 19-31 years). After introduction of LTG (median daily dose 200 mg, range 100-300 mg) the mean serum CBZ-E concentration increased by 45% (P < 0.01) and the CBZ-E/CBZ ratio increased by 19% (P < 0.02). In 4 patients these changes were associated with clinical toxicity (dizziness, nausea, diplopia). The possibility of an increase in serum CBZ-E concentrations needs to be considered if toxicity symptoms develop when LTG is added to CBZ therapy.

Type: Article
Title: LAMOTRIGINE-INDUCED CARBAMAZEPINE TOXICITY - AN INTERACTION WITH CARBAMAZEPINE-10,11-EPOXIDE
Keywords: LAMOTRIGINE, CARBAMAZEPINE, CARBAMAZEPINE-10,11-EPOXIDE, DRUG INTERACTION, POTENTIAL ANTIEPILEPTIC DRUG, SEVERE EPILEPSY, ANTICONVULSANT, 11-EPOXIDE, TRIAL, MICE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/144655
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