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Postsynaptic assembly: A role for Wnt signalling

Stamatakou, E; Salinas, PC; (2013) Postsynaptic assembly: A role for Wnt signalling. Developmental Neurobiology , 74 (8) 10.1002/dneu.22138. Green open access

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Abstract

Synapse formation requires the coordinated formation of the presynaptic terminal, containing the machinery for neurotransmitter release, and the postsynaptic side that possesses the machinery for neurotransmitter reception. For coordinated pre- and postsynaptic assembly signals across the synapse are required. Wnt secreted proteins are well-known synaptogenic factors that promote the recruitment of presynaptic components in diverse organisms. However, recent studies demonstrate that Wnts act directly onto the postsynaptic side at both central and peripheral synapses to promote postsynaptic development and synaptic strength. This review focuses on the role of Wnts in postsynaptic development at central synapses and the neuromuscular junction. © 2013 Wiley Periodicals, Inc. Develop Neurobiol, 2013.

Type: Article
Title: Postsynaptic assembly: A role for Wnt signalling
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/dneu.22138
Publisher version: http://dx.doi.org/10.1002/dneu.22138
Language: English
Additional information: © 2013 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: NMJ, dendritic spines, excitatory and inhibitory synapse
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1443247
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