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In vitro evaluation of samarium (III) oxide as a bone substituting material

Herath, HMTU; Di Silvio, L; Evans, JRG; (2010) In vitro evaluation of samarium (III) oxide as a bone substituting material. J BIOMED MATER RES A , 94A (1) 130 - 136. 10.1002/jbm.a.32667.

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Abstract

The biocompatibility of natural samarium (III) oxide, which has previously been used for treatment in bone-related diseases was determined as a first step in its evaluation as a bone implant material. Assessment for 28 days using osteoblast-like cells revealed no indications of cytotoxicity. The cells adhered and proliferated on the surface. Furthermore, the differentiation and mineralization were observed, indicating a normal biological response of the cells on the samarium (III) oxide surface. The in vitro, short term biocompatibility assessment of this oxide has indicated its biosafety with no damaging toxic effects on the cells and biofunctionality; with an appropriate cell response for a bone-contacting material. Hence, samarium (III) oxide deserves recognition in the field of biomaterials for its excellent in vitro performance and demonstrates that the class of potential bioceramics may be larger than previously thought. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res 94A: 130-136, 2010

Type:Article
Title:In vitro evaluation of samarium (III) oxide as a bone substituting material
DOI:10.1002/jbm.a.32667
Keywords:lanthanides, samarium (III) oxide, biocompatibility, cytotoxicity, cell culture, DIAMINE TETRAMETHYLENE PHOSPHONATE, TOXICITY, GROWTH, DIFFERENTIATION, OSTEOSARCOMA, OSTEOBLASTS, METASTASES, PHENOTYPE, CELLS, ASSAY
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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