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PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

Salvesen, HB; MacDonald, N; Ryan, A; Jacobs, IJ; Lynch, ED; Akslen, LA; Das, S; (2001) PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma. INT J CANCER , 91 (1) 22 - 26.

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Abstract

Loss of heterozygosity and mutations in the PTEN (MMACI) tumor suppressor gene are frequent in endometrial carcinoma. Promoter hypermethylation has recently been identified as an alternative mechanism of tumor suppressor gene inactivation in cancer, but its importance in the PTEN gene in endometrial carcinoma is unknown. The purpose of our study was to assess the frequency of promoter methylation of the PTEN gene and to determine its correlation with clinicopathologic variables in a prospective and population-based series of endometrial carcinomas with complete follow-up. Presence of PTEN promoter methylation was seen in 26 of 138 patients(19%). Methylation was significantly associated with metastatic disease (p = 0.01) and a microsatellite unstable phenotype (p = 0.006), In conclusion, we find that PTEN promoter methylation is relatively frequent in endometrial carcinoma, Its association with metastatic disease and microsatellite instability implicates its importance in the development of this tumor type, (C) 2001 Wiley-Liss, Inc.

Type: Article
Title: PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
Keywords: PTEN, endometrial cancer, methylation, microsatellite instability, prognosis, TUMOR-SUPPRESSOR GENE, PROSTATE-CANCER, DNA METHYLATION, HMLH1 PROMOTER, PTEN/MMAC1, EXPRESSION, MUTATIONS, IDENTIFICATION, INACTIVATION, FREQUENT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: http://discovery.ucl.ac.uk/id/eprint/143934
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