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Survival analysis in familial ovarian cancer, a case control study

Zweemer, RP; Verheijen, RHM; Coebergh, JWW; Jacobs, IJ; van Diest, PJ; Gille, JJP; Skates, S; ... Kenemans, P; + view all (2001) Survival analysis in familial ovarian cancer, a case control study. EUR J OBSTET GYN R B , 98 (2) 219 - 223.

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Abstract

Objective: familial ovarian cancer patients have been found to differ from sporadic cases, clinically as well as in the molecular make-up of the tumour. Here, a case control study is performed to analyse potential differences in survival. Study design: 31 families with a strong history of ovarian and/or breast cancer presenting to a family cancer clinic 44 ovarian cancer patients were included. Each patient was matched for age and stage with controls from a cancer registry. Survival rates and the effect of several prognostic factors were analysed. Results: median survival in the study group differed significantly from controls. A survival benefit for familial cases was maintained up to 5 years after diagnosis. Long-term survival was equally poor in both groups. Conclusion: the difference in survival between familial ovarian cancer cases and matched controls may reflect differences in biological behaviour. This may have important implications for the management and prevention of familial ovarian cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Type: Article
Title: Survival analysis in familial ovarian cancer, a case control study
Keywords: ovarian cancer, hereditary, survival, BRCA1, BRCA2, DEOXYRIBONUCLEIC-ACID PLOIDY, GERMLINE MUTATIONS, PROGNOSTIC FACTORS, BRCA2 GENE, STAGE-III, BREAST, CARCINOMA, NETHERLANDS, PACLITAXEL, FEATURES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
URI: http://discovery.ucl.ac.uk/id/eprint/143933
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