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Investigation of cerebral haemodynamics by near-infrared spectroscopy in young healthy volunteers reveals posture-dependent spontaneous oscillations

Tachtsidis, I; Elwell, CE; Leung, TS; Lee, CW; Smith, M; Delpy, DT; (2004) Investigation of cerebral haemodynamics by near-infrared spectroscopy in young healthy volunteers reveals posture-dependent spontaneous oscillations. PHYSIOL MEAS , 25 (2) 437 - 445. 10.1088/0967-3334/25/2/003.

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Abstract

Autonomic reflexes enable the cardiovascular system to respond to gravitational displacement of blood during changes in posture. Spontaneous oscillations present in the cerebral and systemic circulation of healthy subjects have demonstrated a regulatory role. This Study assessed the dynamic responses of the cerebral and systemic circulation upon standing up and the posture dependence of spontaneous oscillations. In ten young healthy volunteers, blood pressure and cerebral haemodynamics were continuously monitored non-invasively using the Portapres(R) and near-infrared spectroscopy (NIRS), respectively. Oscillatory changes in the cerebral NIRS signals and the diastolic blood pressure (DBP) signal have been identified by the fast Fourier analysis. Blood pressure increased during standing and returned to basal level when volunteers sat on a chair. The mean value of cerebral tissue oxygen index (TOI) as measured by NIRS did not demonstrate any significant changes. Oscillatory changes in DBP, oxyhaemoglobin concentration [O(2)Hb] and TOI showed a significant increase when subjects were standing. Investigation of the low frequency component (similar to0.1 Hz) of these fluctuations revealed posture dependence associated with activation of autonomic reflexes. Systemic and cerebral changes appeared to preserve adequate blood flow and cerebral perfusion during standing in healthy volunteers. Oscillatory changes in [O(2)Mb] and TOI, which may be related to the degree of cerebral sympathetic stimulation, are posture dependent in healthy subjects.

Type:Article
Title:Investigation of cerebral haemodynamics by near-infrared spectroscopy in young healthy volunteers reveals posture-dependent spontaneous oscillations
DOI:10.1088/0967-3334/25/2/003
Keywords:posture changes, near-infrared spectroscopy, spontaneous oscillations, sympathetic stimulation, TOI, cerebral circulation, LOW-FREQUENCY OSCILLATIONS, HEAD-UP TILT, OXYGEN SUFFICIENCY, ARTERIAL-PRESSURE, HUMAN ADULTS, BLOOD-FLOW, ACTIVATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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