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How environment geometry affects grid cell symmetry and what we can learn from it

Krupic, J; Bauza, M; Burton, S; Lever, C; O'Keefe, J; (2014) How environment geometry affects grid cell symmetry and what we can learn from it. Philosophical Transactions of the Royal Society B: Biological Sciences , 369 (1635) , Article 20130188. 10.1098/rstb.2013.0188. Green open access

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Abstract

The mammalian hippocampal formation provides neuronal representations of environmental location but the underlying mechanisms are unclear. The majority of cells in medial entorhinal cortex and parasubiculum show spatially periodic firing patterns. Grid cells exhibit hexagonal symmetry and form an important subset of this more general class. Occasional changes between hexagonal and non-hexagonal firing patterns imply a common underlying mechanism. Importantly, the symmetrical properties are strongly affected by the geometry of the environment. Here, we introduce a field-boundary interaction model where we demonstrate that the grid cell pattern can be formed from competing place-like and boundary inputs. We show that the modelling results can accurately capture our current experimental observations.

Type: Article
Title: How environment geometry affects grid cell symmetry and what we can learn from it
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rstb.2013.0188
Publisher version: http://dx.doi.org/10.1098/rstb.2013.0188
Language: English
Additional information: © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. Audio files of the 'Space in the brain: cells, circuits, codes and cognition' Royal Society Discussion Meeting can be found at http://royalsociety.org/events/2013/brain-circuits-cognition/. Access by clicking the button next to the speaker's name.
Keywords: Border cell, boundary cell, grid cell, hippocampus, spatially periodic cells, symmetry
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: http://discovery.ucl.ac.uk/id/eprint/1437623
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