Rieux, A;
Eriksson, A;
Li, M;
Sobkowiak, B;
Weinert, LA;
Warmuth, V;
Ruiz-Linares, A;
... Balloux, F; + view all
(2014)
Improved calibration of the human mitochondrial clock using ancient genomes.
Molecular Biology and Evolution
, 31
(10)
pp. 2780-2792.
10.1093/molbev/msu222.
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Abstract
Reliable estimates of the rate at which DNA accumulates mutations (the substitution rate) are crucial for our understanding of the evolution and past demography of virtually any species. In humans, there are considerable uncertainties around these rates, with substantial variation among recent published estimates. Substitution rates have traditionally been estimated by associating dated events to the root (e.g. the divergence between humans and chimpanzees) or to internal nodes in a phylogenetic tree (e.g. first entry into the Americas). The recent availability of ancient mtDNA sequences allows for a more direct calibration by assigning the age of the sequenced samples to the tips within the human phylogenetic tree. But studies also vary greatly in the methodology employed and in the sequence panels analysed, making it difficult to tease apart the causes for the differences between previous estimates. To clarify this issue, we compiled a comprehensive dataset of 350 ancient and modern human complete mtDNA genomes, among which 146 were generated for the purpose of this study, and estimated substitution rates using calibrations based both on dated nodes and tips. Our results demonstrate that, for the same dataset, estimates based on individual dated tips are far more consistent with each other than those based on nodes and should thus be considered as more reliable.
| Type: | Article |
|---|---|
| Title: | Improved calibration of the human mitochondrial clock using ancient genomes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/molbev/msu222 |
| Publisher version: | http://dx.doi.org/10.1093/molbev/msu222 |
| Language: | English |
| Additional information: | Copyright © The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Bayesian phylogenetic inference, mitochondrial substitution rates, divergence times, human, calibration strategy, ancient genomes, molecular clock |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1437278 |
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