UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Physicochemical aspects of the transdermal delivery of Bupranolol

Green, PG; Hadgraft, J; Wolff, M; (1989) Physicochemical aspects of the transdermal delivery of Bupranolol. International Journal of Pharmaceutics , 55 (2-3) pp. 265-269. 10.1016/0378-5173(89)90050-1.

Full text not available from this repository.

Abstract

The skin absorption of Bupranolol has been measured in an assessment of the feasibility of delivering this drug transdermally. Basic physicochemical parameters such as partitioning are influenced by the presence of oleic and lauric acids. It is possible to enhance the transfer of Bupranolol across a model isopropyl myristate membrane by an ion pair mechanism involving these two fatty acids. They did not, however, significantly enhance transfer across in vitro human skin. A kinetic model based on physicochemical parameters can predict satisfactorily the transdermal delivery of this β-blocker. © 1989.

Type: Article
Title: Physicochemical aspects of the transdermal delivery of Bupranolol
DOI: 10.1016/0378-5173(89)90050-1
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: http://discovery.ucl.ac.uk/id/eprint/1436651
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item