Masania, J and Li, JJ and Smerdon, SJ and Macmillan, D (2010) Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N -> S acyl transfer. ORG BIOMOL CHEM , 8 (22) 5113 - 5119. 10.1039/c0ob00363h.
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Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N -> S acyl transfer.
|Title:||Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N -> S acyl transfer|
|Keywords:||EXPRESSED PROTEIN LIGATION, TGF-BETA RECEPTOR, CHEMOSELECTIVE LIGATION, GLYCOPEPTIDE SYNTHESIS, SPLIT INTEINS, LIVING CELLS, PEPTIDE, GLYCOSYLATION, STRATEGIES, CHEMISTRY|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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