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Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N -> S acyl transfer

Masania, J; Li, JJ; Smerdon, SJ; Macmillan, D; (2010) Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N -> S acyl transfer. ORG BIOMOL CHEM , 8 (22) 5113 - 5119. 10.1039/c0ob00363h.

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Abstract

Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N -> S acyl transfer.

Type:Article
Title:Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N -> S acyl transfer
DOI:10.1039/c0ob00363h
Keywords:EXPRESSED PROTEIN LIGATION, TGF-BETA RECEPTOR, CHEMOSELECTIVE LIGATION, GLYCOPEPTIDE SYNTHESIS, SPLIT INTEINS, LIVING CELLS, PEPTIDE, GLYCOSYLATION, STRATEGIES, CHEMISTRY
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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