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Utilization of microfluidic V-junction device to prepare surface itraconazole adsorbed nanospheres.

Kucuk, I; Ahmad, Z; Edirisinghe, M; Orlu-Gul, M; (2014) Utilization of microfluidic V-junction device to prepare surface itraconazole adsorbed nanospheres. Int J Pharm , 472 (1-2) pp. 339-346. 10.1016/j.ijpharm.2014.06.023. Green open access

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Abstract

Itraconazole is widely used as an anti-fungal drug to treat infections. However its poor aqueous solubility results in low bioavailability. The aim of the present study was to improve the drug release profile by preparing surface itraconazole adsorbed polymethylsilsesquioxane (PMSQ) nanospheres using a V-junction microfluidic (VJM) device. In order to generate nanospheres with rough surface, the process flow rate of Perfluorohexane (PFH) was set between 50 and 300 μl min(-1) while the flow rate of PMSQ and itraconazole solution were constant at 300 μl min(-1). Variations in the PFH flow rate enable the controlled size generation of nanospheres. PMSQ nanospheres adsorbing itraconazole were characterized by SEM, FTIR and Zetasizer. The release of itraconazole from PMSQ nanosphere surface was measured using UV spectroscopy. Nanosphere formulations with a range of sphere size (120, 320 and 800nm diameter) were generated and drug release was studied. 120nm itraconazole coated PMSQ nanospheres were found to present highest drug encapsulation efficiency and 13% drug loading in a more reproducible manner compared to 320nm and 800nm sized nanosphere formulations. Moreover 120nm itraconazole coated PMSQ nanospheres (encapsulation efficiency: 88%) showed higher encapsulation efficiency compared to 320nm (encapsulation efficiency: 74%) and 800nm (encapsulation efficiency: 62%) sized nanosphere formulations. The itraconazole coated PMSQ nanospheres were prepared continuously at rate of 2.6×10(6) per minute via VJM device. Overall the VJM device enabled the preparation of monodisperse surface itraconazole adsorbed nanospheres with controlled in vitro drug release profile.

Type: Article
Title: Utilization of microfluidic V-junction device to prepare surface itraconazole adsorbed nanospheres.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2014.06.023
Publisher version: http://dx.doi.org/10.1016/j.ijpharm.2014.06.023
Language: English
Additional information: Copyright 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: Surface drug adsorbed, V-junction microfluidic device, drug delivery, itraconazole, nanospheres
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1432958
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