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APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD.

Manning, EN; Barnes, J; Cash, DM; Bartlett, JW; Leung, KK; Ourselin, S; Nick C. Fox1 for the Alzheimer's Disease NeuroImaging Initiative, ; (2014) APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD. PLoS One , 9 (5) , Article e97608. 10.1371/journal.pone.0097608. Green open access

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Abstract

To investigate whether APOE ε4 carriers have higher hippocampal atrophy rates than non-carriers in Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brain atrophy rates.

Type: Article
Title: APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0097608
Publisher version: http://dx.doi.org/10.1371/journal.pone.0097608
Additional information: © 2014 Manning et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: http://discovery.ucl.ac.uk/id/eprint/1431334
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