Byrne, GW;
Azimzadeh, AM;
Ezzelarab, M;
Tazelaar, HD;
Ekser, B;
Pierson, RN;
Robson, SC;
... McGregor, CG; + view all
(2013)
Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection.
Xenotransplantation
, 20
(5)
292 - 307.
10.1111/xen.12050.
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Abstract
The histopathology of cardiac xenograft rejection has evolved over the last 20 yr with the development of new modalities for limiting antibody-mediated injury, advancing regimens for immune suppression, and an ever-widening variety of new donor genetics. These new technologies have helped us progress from what was once an overwhelming anti-Gal-mediated hyperacute rejection to a more protracted anti-Gal-mediated vascular rejection to what is now a more complex manifestation of non-Gal humoral rejection and coagulation dysregulation. This review summarizes the changing histopathology of Gal- and non-Gal-mediated cardiac xenograft rejection and discusses the contributions of immune-mediated injury, species-specific immune-independent factors, transplant and therapeutic procedures, and donor genetics to the overall mechanism(s) of cardiac xenograft rejection.
| Type: | Article |
|---|---|
| Title: | Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection. |
| Location: | Denmark |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/xen.12050 |
| Publisher version: | http://dx.doi.org/10.1111/xen.12050 |
| Language: | English |
| Additional information: | © 2013 The Authors. Xenotransplantation Published by John Wiley and Sons Ltd This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. PMCID: PMC4126170 |
| Keywords: | Gal epitope, cardiac transplantation, coagulation, complement activation, orthotopic transplantation, xenotransplantation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1430446 |
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