UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Role of DAT-SPECT in the diagnostic work up of Parkinsonism

Scherfler, C; Schwarz, J; Antonini, A; Grosset, D; Valldeoriola, F; Marek, K; Oertel, W; ... Poewe, W; + view all (2007) Role of DAT-SPECT in the diagnostic work up of Parkinsonism. MOVEMENT DISORD , 22 (9) 1229 - 1238. 10.1002/mds.21505.

Full text not available from this repository.

Abstract

The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT-SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug-induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression. (c) 2007 Movement Disorder Society

Type: Article
Title: Role of DAT-SPECT in the diagnostic work up of Parkinsonism
DOI: 10.1002/mds.21505
Keywords: dopamine transporter, SPECT, Parkinson's disease, differential diagnosis, STRIATAL DOPAMINE TRANSPORTER, MULTIPLE SYSTEM ATROPHY, PROGRESSIVE SUPRANUCLEAR PALSY, BETA-CIT SPECT, PSYCHOGENIC MOVEMENT-DISORDERS, SLEEP BEHAVIOR DISORDER, IN-VIVO DEMONSTRATION, LEWY BODIES, VASCULAR PARKINSONISM, DISEASE PROGRESSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/143023
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item