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Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit

Lamsa, KP; Heeroma, JH; Somogyi, P; Rusakov, DA; Kullmann, DM; (2007) Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit. SCIENCE , 315 (5816) 1262 - 1266. 10.1126/science.1137450.

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Abstract

Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian": It is induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.

Type: Article
Title: Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit
DOI: 10.1126/science.1137450
Keywords: AMPA RECEPTORS, INWARD RECTIFICATION, THETA OSCILLATIONS, IN-VIVO, INTERNEURONS, EXPRESSION, ACTIVATION, SYNAPSES, INPUT, MODEL
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: http://discovery.ucl.ac.uk/id/eprint/143008
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