Hassan, A;
Lee, P;
Maggina, P;
Xu, JH;
Moreira, D;
Slatter, M;
Nademi, Z;
... Qasim, W; + view all
(2014)
Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency.
Journal of Allergy and Clinical Immunology
, 133
(6)
pp. 1660-1666.
10.1016/j.jaci.2014.02.042.
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Abstract
Severe combined immunodeficiency (SCID) can be cured by using allogeneic hematopoietic stem cell transplantation, and the absence of host immunity often obviates the need for preconditioning. Depending on the underlying genetic defect and when blocks in differentiation occur during lymphocyte ontogeny, infants with SCID have absent or greatly reduced numbers of functional T cells. Natural killer (NK) cell populations are usually absent in the SCID-X1 and Janus kinase 3 forms of SCID and greatly reduced in adenosine deaminase deficiency SCID but often present in other forms of the disorder.
| Type: | Article |
|---|---|
| Title: | Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jaci.2014.02.042 |
| Publisher version: | http://dx.doi.org/10.1016/j.jaci.2014.02.042 |
| Language: | English |
| Additional information: | © 2014 American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
| Keywords: | Severe combined immunodeficiency, adenosine deaminase deficiency, chimerism, conditioning, engraftment, natural killer cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1429055 |
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