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Endothelin

Grant, K; Loizidou, M; Taylor, I; (2006) Endothelin. pp. 447-452. 10.1016/B978-012369442-3/50067-2.

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Abstract

The potent vasoconstrictor peptide endothelin 1 (ET-1) is one of a family of three multifunctional peptides, namely, ET-1, ET-2, and ET-3. The ET physiological effect is exerted via ETA and ETB, which are G-protein coupled transmembrane receptors (GPCR) found in both vascular and nonvascular tissues. The ETA receptor has varying affinities for each isoform (ET-1 > ET-2 > ET-3), whereas the ETB receptor shows no selective affinity for any of the ET subtypes. The consequences of ET-1 induced receptor stimulation are complex in that many intracellular pathways can be activated. ET-1 has been shown to stimulate growth of several human cancer cell lines in vitro including colorectal, ovarian, and prostate cancer, Kaposi's sarcoma, and melanoma cells. Endothelin-1 may also facilitate tumor growth through promotion of angiogenesis. Human umbilical vein endothelial cells (Huvecs) actively produce and secrete ET-1, while simultaneously expressing the ETB receptor, suggesting autocrine activity. ET-1 also potentiates the effect of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) on human smooth muscle cells, suggesting interactions with other tyrosine kinase receptors (TKR). © 2006 Elsevier Inc. All rights reserved.

Type: Article
Title: Endothelin
DOI: 10.1016/B978-012369442-3/50067-2
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: http://discovery.ucl.ac.uk/id/eprint/1429024
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