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Glycaemic fall after a glucose load. A population-based study.

Casiglia, E; Tikhonoff, V; Caffi, S; Bascelli, A; Guglielmi, F; Mazza, A; Martini, B; ... Pessina, AC; + view all (2010) Glycaemic fall after a glucose load. A population-based study. Nutr Metab Cardiovasc Dis , 20 (10) pp. 727-733. 10.1016/j.numecd.2009.06.012.

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Abstract

BACKGROUND AND AIMS: A blood glucose (BG) fall after an oral glucose load has never been described previously at a population level. This study was aimed at looking for a plasma glucose trend after an oral glucose load for possible blood glucose fall if any, and for its impact on coronary mortality at a population level. METHODS AND RESULTS: In subjects from an unselected general population, BG and insulin were detected before and 1 and 2h after a 75-g oral glucose load for insulin sensitivity and β-cell function determination. Blood pressure, blood examinations and left ventricular mass were measured, and mortality was monitored for 18.8±7.7 years. According to discriminant analysis, the population was stratified into cluster 0 (1-h BG < fasting BG; n=497) and cluster 1 (1-h BG ≥ fasting BG; n=1733). To avoid any interference of age and sex, statistical analysis was limited to two age-gender-matched cohorts of 490 subjects from each cluster (n=940). Subjects in cluster 0 showed significantly higher insulin sensitivity and β-cell function, lower visceral adiposity and lower blood pressure values. Adjusted coronary mortality was 8 times lower in cluster 0 than 1 (p<0.001). The relative risk of belonging to cluster 1 was 5.40 (95% CI 2.22-13.1). CONCLUSION: It seems that two clusters exist in the general population with respect to their response to an oral glucose load, independent of age and gender. Subjects who respond with a BG decrease could represent a privileged sub-population, where insulin sensitivity and β-cell function are better, some risk factors are less prevalent, and coronary mortality is lower.

Type: Article
Title: Glycaemic fall after a glucose load. A population-based study.
Location: Netherlands
DOI: 10.1016/j.numecd.2009.06.012
Keywords: Adult, Aged, Aged, 80 and over, Analysis of Variance, Blood Glucose, Blood Pressure, Cluster Analysis, Coronary Disease, Female, Follow-Up Studies, Glucose Tolerance Test, Glycemic Index, Humans, Insulin, Insulin Resistance, Male, Metabolic Syndrome, Middle Aged, Obesity, Risk Factors, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/1428797
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