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High dietary fiber intake prevents stroke at a population level.

Casiglia, E; Tikhonoff, V; Caffi, S; Boschetti, G; Grasselli, C; Saugo, M; Giordano, N; ... Palatini, P; + view all (2013) High dietary fiber intake prevents stroke at a population level. Clin Nutr , 32 (5) pp. 811-818. 10.1016/j.clnu.2012.11.025.

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Abstract

BACKGROUND & AIMS: This research was aimed at clarifying whether high dietary fiber intake has an impact on incidence and risk of stroke at a population level. METHODS: In 1647 unselected subjects, dietary fiber intake (DFI) was detected in a 12-year population-based study, using other dietary variables, anagraphics, biometrics, blood pressure, heart rate, blood lipids, glucose, insulin, uricaemia, fibrinogenaemia, erytrosedimentation rate, diabetes, insulin resistance, smoking, pulmonary disease and left ventricular hypertrophy as covariables. RESULTS: In adjusted Cox models, high DFI reduced the risk of stroke. In analysis based on quintiles of fiber intake adjusted for confounders, HR for incidence of stroke was lower when the daily intake of soluble fiber was >25 g or that of insoluble fiber was >47 g. In multivariate analyses, using these values as cut-off of DFI, the risk of stroke was lower in those intaking more that the cut-off of soluble (HR 0.31, 0.17-0.55) or insoluble (HR 0.35, 0.19-0.63) fiber. Incidence of stroke was also lower (-50%, p < 0.003 and -46%, p < 0.01, respectively). CONCLUSIONS: Higher dietary DFI is inversely and independently associated to incidence and risk of stroke in general population.

Type: Article
Title: High dietary fiber intake prevents stroke at a population level.
Location: England
DOI: 10.1016/j.clnu.2012.11.025
Keywords: Blood pressure, Cerebrovascular, Cholesterol, Epidemiology, Fiber, Fibre, Human, Population, Risk, Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Dietary Fiber, Female, Humans, Incidence, Italy, Longitudinal Studies, Male, Middle Aged, Prevalence, Risk Factors, Solubility, Stroke, Surveys and Questionnaires, Survival Analysis, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/1428726
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