UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Data linkage reduces loss to follow-up in an observational HIV cohort study

Hill, T; Bansi, L; Sabin, C; Phillips, A; Dunn, D; Anderson, J; Easterbrook, P; ... UK Collaborative HIV Cohort UK CHI, ; + view all (2010) Data linkage reduces loss to follow-up in an observational HIV cohort study. J CLIN EPIDEMIOL , 63 (10) 1101 - 1109. 10.1016/j.jclinepi.2009.12.007.

Full text not available from this repository.

Abstract

Objective: To ascertain the degree of loss to follow-up in a cohort and to identify its predictors.Study Design and Setting: Human immunodeficiency virus (HIV)-infected individuals without CD4 cell counts for a year or more were defined as potentially lost to follow-up (LFU). Multivariable Poisson regression models identified the risk factors for potential LFU. Multivariable logistic regression models compared demographic and clinical characteristics of those who returned for care and those permanently LFU.Results: Of 16,595 patients under follow-up, 43.6% were potentially LFU at least once. Of these, 39.8% were considered permanently LFU and 60.2% were seen again after I year. Of 9,766 episodes when patients were potentially LFU, 59% resulted in the patient returning for care at the same clinic or at a different clinic. Compared with those permanently LFU, patients returning were more likely to have started highly active antiretroviral therapy, to have higher CD4 counts and viral loads, to be younger, and to have had more CD4 tests before LFU. They were less likely to have had a previous episode of potential LFU.Conclusions: A substantial proportion of patients in the UK Collaborative HIV Cohort study are potentially LFU. Data linkage identifies patients returning for care at different centers. Recognition of factors associated with LFU may help reduce this important source of bias in observational databases. (C) 2010 Elsevier Inc. All rights reserved.

Type: Article
Title: Data linkage reduces loss to follow-up in an observational HIV cohort study
DOI: 10.1016/j.jclinepi.2009.12.007
Keywords: Cohort, HIV, Loss to follow-up, Data linkage, Follow-up, Risk factors, RANDOMIZED TRIALS, CONSORT STATEMENT, PREDICTORS, RISK, CARE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/142676
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item