Dean, R;
Zimmer, F;
Mank, JE;
(2014)
The potential role of sexual conflict and sexual selection in shaping the genomic distribution of mito-nuclear genes.
Genome Biology and Evolution
, 6
(5)
1096 -1104.
10.1093/gbe/evu063.
![[thumbnail of 2014_GBE_MitoNuc.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
2014_GBE_MitoNuc.pdf Download (391kB) |
Abstract
Mitochondrial interactions with the nuclear genome represent one of life's most important coevolved mutualisms. In many organisms, mitochondria are maternally inherited, and in these cases, co-transmission between the mitochondrial and nuclear genes differs across different parts of the nuclear genome, with genes on the X chromosome having 2/3 probability of co-transmission, compared to 1/2 for genes on autosomes. These asymmetrical inheritance patterns of mitochondria and different parts of the nuclear genome have the potential to put certain gene combinations in inter-genomic coadaptation or conflict. Previous work in mammals found strong evidence that the X chromosome has a dearth of genes that interact with the mitochondria (mito-nuclear genes), suggesting that inter-genomic conflict might drive genes off the X onto the autosomes for their male-beneficial effects. Here, we developed this idea to test co-adaptation and conflict between mito-nuclear gene combinations across phylogenetically independent sex chromosomes on a far broader scale. We found that, in addition to therian mammals, only C. elegans showed an under-representation of mito-nuclear genes on the sex chromosomes. The remaining species studied showed no overall bias in their distribution of mito-nuclear genes. We discuss possible factors other than inter-genomic conflict that might drive the genomic distribution of mito-nuclear genes.
| Type: | Article |
|---|---|
| Title: | The potential role of sexual conflict and sexual selection in shaping the genomic distribution of mito-nuclear genes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/gbe/evu063 |
| Publisher version: | http://dx.doi.org/10.1093/gbe/evu063 |
| Language: | English |
| Additional information: | © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | Haldane's Sieve, OXPHOS, X chromosome, Z chromosome, sexual conflict |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1426435 |
Archive Staff Only
 |
View Item |
