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Gender-modulated impact of apolipoprotein A5 gene (APOA5)-1131T > C and c.56C > G polymorphisms on lipids, dyslipidernia and metabolic syndrome in Turkish adults

Komurcu-Bayrak, E; Onat, A; Poda, M; Humphries, SE; Palmen, J; Guclu, F; ... Erginel-Unaltuna, N; + view all (2008) Gender-modulated impact of apolipoprotein A5 gene (APOA5)-1131T > C and c.56C > G polymorphisms on lipids, dyslipidernia and metabolic syndrome in Turkish adults. CLIN CHEM LAB MED , 46 (6) 778 - 784. 10.1515/CCLM.2008.161.

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Abstract

Background: Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of the APOA5 -1131T > C and c.56C > G polymorphisms [single nucleotide polymorphism (SNP)] with serum lipids, dyslipidemia [low high-density lipoprotein (HDL)/high triglyceride] and the risk for metabolic syndrome (IMS) in the Turkish Adult Risk Factor study.Methods: We genotyped SNPs using the Taqman allelic discrimination assays in 1564 Turkish adults (51.4% female, mean age 54.1 +/- 11.6 years). MS and dyslipidemia were defined using the criteria of the National Cholesterol Education Program.Results: For both SNPs, rare allele carriers had significantly higher fasting triglyceride levels in both genders, except the c.56G allele in men. The -1131 C allele was associated with lower HDL cholesterol (HDL-C) levels in women. In relation to dyslipidemia, the c.56C > G and haplotype 1 had significant gender-genotype interactions (p < 0.05). Otherwise, both SNPs were significantly associated with dyslipidemia after adjustment for risk factors in women. After similar adjustment, non-carriers of the haplotype 1 (odds ratio=4.1, p=0.003) increased the MS risk in women. However, no significant associations emerged between SNPs and HDL-C, dyslipidemia or IMS in a similar analysis in men.Conclusions: Excess risk for low HDL-C, dyslipidemia and MS is associated with the rare alleles of the APOA5 SNPs and non-carriers of common haplotype in women.

Type:Article
Title:Gender-modulated impact of apolipoprotein A5 gene (APOA5)-1131T > C and c.56C > G polymorphisms on lipids, dyslipidernia and metabolic syndrome in Turkish adults
DOI:10.1515/CCLM.2008.161
Keywords:APOA5 polymorphisms, dyslipidemia, lipids, metabolic syndrome, Turkish population, PLASMA TRIGLYCERIDE LEVELS, CORONARY-HEART-DISEASE, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, YOUNG FINNS, APOA5 GENE, ASSOCIATION, VARIANTS, MEN, CHOLESTEROL
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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