Vaessen, SFC and Schaap, FG and Kuivenhoven, JA and Groen, AK and Hutten, BA and Boekholdt, SM and Hattori, H and Sandhu, MS and Bingham, SA and Luben, R and Palmen, JA and Wareham, NJ and Humphries, SE and Kastelein, JJP and Talmud, PJ and Khaw, KT (2006) Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. J LIPID RES , 47 (9) 2064 - 2070. 10.1194/jlr.M600233-JLR200.
In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study. Both univariate and multivariate apoA-V levels showed no association with future CAD (P = 0.4 and 0.5, respectively). Unexpectedly, there was a significant positive correlation between serum apoA-V and TG in men and women (r = 0.36 and 0.28, respectively, P < 0.001 each) but a negative correlation between apoA-V and LPL mass (r = -0.14 and -0.12 for men and women respectively, P < 0.001 each). The frequency of the c.56C > G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoA-V and TG levels. For -1131T > C, the minor allele was significantly associated with lower apoA-V yet higher TG levels and was overrepresented in cases (P = 0.047). The association of -1131T > C with CAD risk, however, was independent of apoA-V levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V.
|Title:||Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study|
|Open access status:||An open access publication|
|Keywords:||single nucleotide polymorphism, European Prospective Investigation into Cancer and Nutrition epidemiology, APOA5 GENE VARIANTS, LIPOPROTEIN-LIPASE, PLASMA TRIGLYCERIDE, RICH LIPOPROTEINS, RESPONSE ELEMENT, CLUSTER, POLYMORPHISM, HYDROLYSIS, CHINESE, SERUM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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