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Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

Vaessen, SFC; Schaap, FG; Kuivenhoven, JA; Groen, AK; Hutten, BA; Boekholdt, SM; ... Khaw, KT; + view all (2006) Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. Journal of Lipid Research , 47 (9) 2064 - 2070. 10.1194/jlr.M600233-JLR200. Gold open access

Abstract

In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study. Both univariate and multivariate apoA-V levels showed no association with future CAD (P = 0.4 and 0.5, respectively). Unexpectedly, there was a significant positive correlation between serum apoA-V and TG in men and women (r = 0.36 and 0.28, respectively, P < 0.001 each) but a negative correlation between apoA-V and LPL mass (r = -0.14 and -0.12 for men and women respectively, P < 0.001 each). The frequency of the c.56C > G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoA-V and TG levels. For -1131T > C, the minor allele was significantly associated with lower apoA-V yet higher TG levels and was overrepresented in cases (P = 0.047). The association of -1131T > C with CAD risk, however, was independent of apoA-V levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V.

Type:Article
Title:Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
Open access status:An open access publication
DOI:10.1194/jlr.M600233-JLR200
Publisher version:http://dx.doi.org10.1194/jlr.M600233-JLR200
Language:English
Keywords:Single nucleotide polymorphism, european prospective investigation into cancer and nutrition epidemiology, apoa5 gene variants, lipoprotein-lipase, plasma triglyceride, rich lipoproteins, response element, cluster, polymorphism, hydrolysis, chinese, serum
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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