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Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: The cardiovascular health study

Reiner, AP; Diehr, P; Browner, WS; Humphries, SE; Jenny, NS; Cushman, M; Tracy, RP; ... Psaty, BM; + view all (2005) Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: The cardiovascular health study. ATHEROSCLEROSIS , 181 (1) 175 - 183. 10.1016/j.atherosclerosis.2005.01.028.

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Abstract

Inflammatory response genes may influence life span or quality at advanced ages. Using data from the population-based cardiovascular health study (CHS) cohort, we examined the associations between promoter polymorphisms of several inflammation and thrombosis genes with longevity. We ascertained genotypes for interleukin (IL)-6 -174 G/C, beta-fibrinogen -455 G/A, plasminogen activator inhibitor (PAI)-1 -675 4G/5G, and thrombin-activatable fibrinolysis inhibitor (TAFI) -438 G/A in 2224 men and women >= 65 years old at baseline. During 10 years of follow-up, men with the TAFI -438 A/A genotype had decreased mortality due to all causes, and lived, on average, 0.9 more years of life, or 1.1 more years of healthy life, than men with the -438 G allele. The effects of TAFI -438 G/A in women were smaller and not statistically significant. PAI-1 4G/4G genotype appeared to be associated with lower non-cardiovascular mortality in men, but with greater cardiovascular mortality in women. In exploratory analyses, we observed a possible interaction among anti-inflammatory drugs, interleukin-6 -174 C/C genotype, and longevity. These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity. (c) 2005 Published by Elsevier Ireland Ltd.

Type: Article
Title: Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: The cardiovascular health study
DOI: 10.1016/j.atherosclerosis.2005.01.028
Keywords: thrombin-activatable fibrinolysis inhibitor, longevity, inflammation, fibrinolysis, promoter polymorphism, PLASMINOGEN-ACTIVATOR INHIBITOR-1, SINGLE NUCLEOTIDE POLYMORPHISM, CAUSE-SPECIFIC MORTALITY, CORONARY HEART-DISEASE, MYOCARDIAL-INFARCTION, INTERLEUKIN-6 IL-6, ANTIGEN LEVELS, PLASMA-LEVELS, TAFI GENE, FIBRINOLYSIS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/142629
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