Yudkin, JS and Juhan-Vague, I and Hawe, E and Humphries, SE and di Minno, G and Margaglione, M and Tremoli, E and Kooistra, T and Morange, PE and Lundman, P and Mohamed-Ali, V and Hamsten, A and HIFMECH Study Grp, (2004) Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: The HIFMECH study. METABOLISM , 53 (7) 852 - 857. 10.1016/j.metabol.2004.02.004.
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Risk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood. Variables attributed to insulin resistance are associated with low-grade inflammation. A case-control study was performed of 469 male myocardial infarction (MI) survivors aged <60 years and 575 control subjects recruited from centers in northern and southern Europe. Principal factor analysis was used to explore correlations between insulin resistance and inflammatory variables. Three factors resulted: (a) "Metabolic Syndrome" (insulin/proinsulin/triglyceride/body mass index [BMI]); (b) "Inflammation" (fibrinogen/C-reactive protein [CRP]/interleukin-6 [IL-6]); and (c) "Blood Pressure" (systolic and diastolic blood pressure). The "Metabolic Syndrome" factor was related to the "Inflammation" factor (largely independently of obesity), the "Blood Pressure" factor, smoking, and south location (all P less than or equal to .0002). There were significant relationships between all 3 factors and case status (P less than or equal to .0002). Markers of low-grade inflammation are strongly related to metabolic syndrome variables independently of obesity. This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation. (C) 2004 Elsevier Inc. All rights reserved.
|Title:||Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: The HIFMECH study|
|Keywords:||INSULIN-RESISTANCE SYNDROME, TUMOR-NECROSIS-FACTOR, ACUTE MYOCARDIAL-INFARCTION, PROINSULIN-LIKE MOLECULES, APPARENTLY HEALTHY-MEN, MIDDLE-AGED MEN, ADIPOSE-TISSUE, CARDIOVASCULAR-DISEASE, ENDOTHELIAL DYSFUNCTION, FIBRINOLYSIS VARIABLES|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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