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INVOLVEMENT OF PROTEIN-KINASE-C IN THE DELAYED CYTOPROTECTION FOLLOWING SUBLETHAL ISCHEMIA IN RABBIT MYOCARDIUM

BAXTER, GF; GOMA, FM; YELLON, DM; (1995) INVOLVEMENT OF PROTEIN-KINASE-C IN THE DELAYED CYTOPROTECTION FOLLOWING SUBLETHAL ISCHEMIA IN RABBIT MYOCARDIUM. BRIT J PHARMACOL , 115 (2) 222 - 224.

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Abstract

Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.

Type:Article
Title:INVOLVEMENT OF PROTEIN-KINASE-C IN THE DELAYED CYTOPROTECTION FOLLOWING SUBLETHAL ISCHEMIA IN RABBIT MYOCARDIUM
Keywords:ISCHEMIC PRECONDITIONING, 2ND WINDOW OF PROTECTION, MYOCARDIAL PROTECTION, ISCHEMIA, INFARCTION, PROTEIN KINASE C (PKC), CHELERYTHRINE, ISCHEMIA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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