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Antigen processing and presentation: close encounters in the endocytic pathway.

Brodsky, FM; (1992) Antigen processing and presentation: close encounters in the endocytic pathway. Trends Cell Biol , 2 (4) pp. 109-115.

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Abstract

Stimulation of helper T cells by class II molecules occurs when the class II molecules bind and display peptides derived from foreign antigens that have been endocytosed. The formation of peptide-class II complexes requires antigen degradation and exposure of the peptide-binding site of class II molecules, both of which depend on proteolysis and low pH in the endocytic pathway. This review discusses the role of specific compartments of the endocytic pathway in the generation of antigenic peptides, and in the binding of antigenic peptides to newly synthesized class II molecules and those that are internalized from the cell surface.

Type: Article
Title: Antigen processing and presentation: close encounters in the endocytic pathway.
Location: England
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1425371
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