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Non-alcoholic Fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms.

Carter, R; Mouralidarane, A; Soeda, J; Ray, S; Pombo, J; Saraswati, R; Novelli, M; ... Oben, JA; + view all (2014) Non-alcoholic Fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms. PLoS One , 9 (3) , Article e89505. 10.1371/journal.pone.0089505. Green open access

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Abstract

Emerging evidence suggests that maternal obesity (MO) predisposes offspring to obesity and the recently described non-alcoholic fatty pancreas disease (NAFPD) but involved mechanisms remain unclear. Using a pathophysiologically relevant murine model, we here investigated a role for the biological clock - molecular core circadian genes (CCG) in the generation of NAFPD.

Type: Article
Title: Non-alcoholic Fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0089505
Publisher version: http://dx.doi.org/10.1371/journal.pone.0089505
Language: English
Additional information: �© 2014 Carter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3962337
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1425272
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