Halet, G; Marangos, P; FitzHarris, G; Carroll, J; (2003) Ca2+ oscillations at fertilization in mammals. BIOCHEMICAL SOCIETY TRANSACTIONS , 31 907 - 911.
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The mouse egg provided the first direct measurement of Ca2+ oscillations in any cell type. These sperm-induced Ca2+ oscillations occur at a relatively low frequency, and can be detected up to 18-20 IT after sperm-egg fusion. The Ca2+ oscillations consist of two series of transients; the first lasts about 4 h, from metaphase II until interphase of the first cell cycle, and the second lasts the duration of the first mitotic division. This cell-cycle-regulated aspect to the pattern of Ca2+ signalling at fertilization is reflected in the role of the Ca2+ transients in stimulating exit from metaphase arrest. Recent developments have started to shed light on the mechanism initiating Ca2+ oscillations at fertilization, on how the frequency of the oscillations is set, and on what determines their temporal pattern.
|Title:||Ca2+ oscillations at fertilization in mammals|
|Location:||UNIV LIVERPOOL, LIVERPOOL, ENGLAND|
|Keywords:||cell cycle, fertilization, green fluorescent protein, nucleus, phospholipase C, protein kinase C (PKC), sperm, PLASMA-MEMBRANE PTDINS(4,5)P-2, PHOSPHOLIPASE-C ISOFORMS, SEA-URCHIN EGGS, MOUSE OOCYTES, CELL-CYCLE, CALCIUM OSCILLATIONS, INOSITOL 1,4,5-TRISPHOSPHATE, ENDOPLASMIC-RETICULUM, KINASE-ACTIVITY, ACTIVATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology|
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