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Re-thinking the role of motor cortex: Context-sensitive motor outputs?

Gandolla, M; Ferrante, S; Molteni, F; Guanziroli, E; Frattini, T; Martegani, A; Ferrigno, G; ... Ward, NS; + view all (2014) Re-thinking the role of motor cortex: Context-sensitive motor outputs? Neuroimage , 91 pp. 366-374. 10.1016/j.neuroimage.2014.01.011. Green open access

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Abstract

The standard account of motor control considers descending outputs from primary motor cortex (M1) as motor commands and efference copy. This account has been challenged recently by an alternative formulation in terms of active inference: M1 is considered as part of a sensorimotor hierarchy providing top-down proprioceptive predictions. The key difference between these accounts is that predictions are sensitive to the current proprioceptive context, whereas efference copy is not. Using functional electric stimulation to experimentally manipulate proprioception during voluntary movement in healthy human subjects, we assessed the evidence for context sensitive output from M1. Dynamic causal modeling of functional magnetic resonance imaging responses showed that FES altered proprioception increased the influence of M1 on primary somatosensory cortex (S1). These results disambiguate competing accounts of motor control, provide some insight into the synaptic mechanisms of sensory attenuation and may speak to potential mechanisms of action of FES in promoting motor learning in neurorehabilitation.

Type: Article
Title: Re-thinking the role of motor cortex: Context-sensitive motor outputs?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroimage.2014.01.011
Publisher version: http://dx.doi.org/10.1016/j.neuroimage.2014.01.011
Additional information: © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
Keywords: ADF, BA, Brodmann area, DCM, EPSP, FES, FES-induced ADF concurrently with voluntary movement by the subject, FES-induced ADF, while the subject remains relaxed, FP, FV, M1, MNI, MRI, Montreal Neurological Institute, P, PR, ROI, S1, SII, V, ankle dorsiflexion, dynamic causal modeling, excitatory postsynaptic potential, fMRI, functional electrical stimulation, functional magnetic resonance imaging, magnetic resonance imaging, motor cortex, pariental rostroventral area, passive dorsiflexion (by the experimenter) of the subject’s ankle, primary motor cortex, primary somatosensory cortex, proprioception, region of interest, secondary somatosensory cortex, voluntary ADF
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1424403
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