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A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery.

Gooding, M; Adigbli, D; Edith Chan, AW; Melander, RJ; Macrobert, AJ; Selwood, DL; (2014) A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery. Chem Biol Drug Des , 84 (1) pp. 24-35. 10.1111/cbdd.12295. Green open access

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Abstract

A wider application of siRNA and miRNA based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modelled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC. This article is protected by copyright. All rights reserved.

Type: Article
Title: A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/cbdd.12295
Publisher version: http://dx.doi.org/10.1111/cbdd.12295
Additional information: © 2014 The Authors. Chemical Biology & Drug Design Published by John Wiley & Sons Ltd. doi: 10.1111/cbdd.12295 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: biophysical chemistry; carbohydrate; chemical biology; lipid; nucleic acid; RNAi and antisense techniques
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School > Clinical and Professional Practice Unit
URI: http://discovery.ucl.ac.uk/id/eprint/1423601
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