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Cotransmission

Burnstock, G; (2012) Cotransmission. pp. 27-33. 10.1016/B978-0-12-386525-0.00005-6.

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Abstract

This chapter focuses on cotransmission as an integral feature of neurotransmission. The neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) are the principal transmitters of primary afferent nerves and have been shown to coexist in the same terminals. The enteric nervous system contains several hundred million neurons located in the myenteric plexus between muscle coats and the submucous plexus. A cotransmitter can feedback on presynaptic receptors that increase or decrease its own release or that of its cotransmitter(s). There are an increasing number of reports of the synergistic actions of cotransmitters. Adenosine 5-triphosphate (ATP) noradrenaline (NA) released from sympathetic nerves have synergistic actions on smooth muscle of vas deferens and blood vessels, and ATP released with acetylcholine (ACh) from motoneurons facilitates the nicotinic actions of ACh at the skeletal neuromuscular junction. Some costored and coreleased substances can act as long-term (trophic) factors, as well as neurotransmitters. For example, ATP can act on P2 receptors, or P1 (adenosine) receptors after ectoenzymatic breakdown, to promote vascular cell proliferation, motility, differentiation or death. © 2012 Elsevier Inc. All rights reserved.

Type: Article
Title: Cotransmission
DOI: 10.1016/B978-0-12-386525-0.00005-6
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1422671
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