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Purinergic Neurotransmission and Nucleotide Receptors

Burnstock, G; (2012) Purinergic Neurotransmission and Nucleotide Receptors. pp. 87-93. 10.1016/B978-0-12-386525-0.00018-4.

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Abstract

This chapter focuses on purinergic neurotransmission and nucleotide receptors. The proportions of ATP and noradrenaline (NA) vary in different tissues and species, during development and ageing and in different pathophysiological conditions. Acetylcholine (ACh) and ATP are cotransmitters in parasympathetic nerves supplying the urinary bladder. Purinergic signaling in the brain stem is involved in control of autonomic functions, including cardiovascular and respiratory control and in the regulation of hormone secretion and body temperature at the hypothalamic level. The nucleus tractus solitarius (NTS) is a major integrative center of the brain stem involved in reflex control of the cardiovascular system; stimulation of P2X receptors in the NTS evokes hypotension. Adenoviral expression of a P2X1 receptor-green fluorescent protein construct in vas deferens shows the receptor to be localized in clusters, with larger ones apposing nerve varicosities. The formation of oligomers by P2Y receptors is likely to be widespread and to greatly increase the diversity of purinergic signaling. P2X receptors are often expressed in the same cells as P2Y receptors. Thus, there is the possibility of bidirectional cross-talk between these two families of nucleotide-sensitive receptors. © 2012 Elsevier Inc. All rights reserved.

Type: Article
Title: Purinergic Neurotransmission and Nucleotide Receptors
DOI: 10.1016/B978-0-12-386525-0.00018-4
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1422670
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