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High concentration of zinc in sub-retinal pigment epithelial deposits

Lengyel, I; Flinn, JM; Peto, T; Linkous, DH; Cano, K; Bird, AC; Lanzirotti, A; (2007) High concentration of zinc in sub-retinal pigment epithelial deposits. EXP EYE RES , 84 (4) 772 - 780. 10.1016/j.exer.2006.12.015.

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Abstract

One of the hallmarks of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in Western societies, is the accumulation of sub-retinal pigment epithelial deposits (sub-RPE deposits), including drusen and basal laminar deposits, in Bruch's membrane (BM). The nature and the underlying mechanisms of this deposit formation are not fully understood. Because we know that zinc contributes to deposit formation in neurodegenerative diseases, we tested the hypothesis that zinc might be involved in deposit formation in AMD. Using zinc specific fluorescent probes and microprobe synchrotron X-ray fluorescence we showed that sub-RPE deposits in post-mortem human tissues contain unexpectedly high concentrations of zinc, including abundant bio-available (ionic and/or loosely protein bound) ions. Zinc accumulation was especially high in the maculae of eyes with AMD. Internal deposit structures are especially enriched in bio-available zinc. Based on the evidence provided here we suggest that zinc plays a role in sub-RPE deposit formation in the aging human eye and possibly also in the development and/or progression of AMD. (c) 2007 Elsevier Ltd. All rights reserved.

Type: Article
Title: High concentration of zinc in sub-retinal pigment epithelial deposits
DOI: 10.1016/j.exer.2006.12.015
Keywords: zinc, drusen, sub-RPE deposit, Bruch's membrane, retinal pigment epithelium, age-related macular degeneration, complement factor H, trace element, AGE-RELATED MACULOPATHY, COMPLEMENT FACTOR-H, MACULAR DEGENERATION, DRUSEN FORMATION, ALZHEIMERS-DISEASE, BRUCHS MEMBRANE, HUMAN RETINA, X-RAY, SUBCELLULAR-LOCALIZATION, ELECTRON-MICROSCOPY
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: http://discovery.ucl.ac.uk/id/eprint/14224
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