UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Marfan syndrome and pregnancy: maternal and neonatal outcomes

Curry, R; Gelson, E; Swan, L; Dob, D; Babu-Narayan, S; Gatzoulis, M; Steer, P; (2014) Marfan syndrome and pregnancy: maternal and neonatal outcomes. BJOG: an International Journal of Obstetrics and Gynaecology 10.1111/1471-0528.12515. Green open access

[thumbnail of bjo12515.pdf]
Preview
PDF
bjo12515.pdf
Available under License : See the attached licence file.

Download (195kB)

Abstract

Objective To report outcomes in a recent series of pregnancies in women with Marfan syndrome (MFS). Design Retrospective case note review. Setting Tertiary referral unit (Chelsea and Westminster and Royal Brompton Hospitals). Sample Twenty-nine pregnancies in 21 women with MFS between 1995 and 2010. Methods Multidisciplinary review of case records. Main outcome measures Maternal and neonatal mortality and morbidity of patients with MFS and healthy controls. Results There were no maternal deaths. Significant cardiac complications occurred in five pregnancies (17%): one woman experienced a type–A aortic dissection; two women required cardiac surgery within 6 months of delivery; and a further two women developed impaired left ventricular function during the pregnancy. Women with MFS were also more likely to have obstetric complications (OR 3.29, 95% CI 1.30–8.34), the most frequent of which was postpartum haemorrhage (OR 8.46, 95% CI 2.52–28.38). There were no perinatal deaths, although babies born to mothers with MFS were delivered significantly earlier than those born to the control group (median 39 versus 40 weeks of gestation, Mann–Whitney U–test, P = 0.04). These babies were also significantly more likely to be small for gestational age (24% in the MFS group versus 6% in the controls; OR 4.95, 95% CI 1.58–15.55). Conclusions Pregnancy in women with MFS continues to be associated with significant rates of maternal, fetal, and neonatal complications. Effective pre-pregnancy counselling and meticulous surveillance during pregnancy, delivery, and the puerperium by an experienced multidisciplinary team are warranted for women with MFS.

Type: Article
Title: Marfan syndrome and pregnancy: maternal and neonatal outcomes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.12515
Publisher version: http://dx.doi.org/10.1111/1471-0528.12515
Additional information: © 2014 The Authors BJOG An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made
Keywords: Marfan syndrome, pregnancy
UCL classification: UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1421174
Downloads since deposit
199Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item