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A mechanosensory pathway to the Drosophila circadian clock

Simoni, A; Wolfgang, W; Topping, MP; Kavlie, RG; Stanewsky, R; Albert, JT; (2014) A mechanosensory pathway to the Drosophila circadian clock. Science , 343 (6170) 525 - 528. 10.1126/science.1245710. Green open access

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Abstract

Circadian clocks attune the physiology of virtually all living organisms to the diurnal cycles of their environments. In metazoan animals, multiple sensory input pathways have been linked to clock synchronization with the environmental cycle (entrainment). Extrinsic entrainment cues include light and temperature. We show that (12-hour:12-hour) cycles of vibration and silence (VS) are sufficient to synchronize the daily locomotor activity of wild-type Drosophila melanogaster. Behavioral synchronization to VS cycles required a functional clock and functional chordotonal organs and was accompanied by phase-shifts of the daily oscillations of PERIOD protein concentrations in brain clock neurons. The feedback from mechanosensory-and particularly, proprioceptive-organs may help an animal to keep its circadian clock in sync with its own, stimulus-induced activities.

Type: Article
Title: A mechanosensory pathway to the Drosophila circadian clock
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.1245710
Publisher version: http://dx.doi.org/10.1126/science.1245710
Language: English
Additional information: This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in in Science, 31 January 2014, Vol. 343 no. 6170 pp. 525-528 DOI: 10.1126/science.1245710
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1421083
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