Rintelen, C and Mannhalter, C and Ireland, H and Lane, DA and Knobl, P and Lechner, K and Pabinger, I (1996) Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden. BRIT J HAEMATOL , 93 (2) 487 - 490.
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In 29 patients (17 females) homozygous Arg 506 Gin mutation (FV Leiden) was identified. 25 had been investigated because of venous thromboembolism (VTE); four asymptomatic patients were found during family studies.The first VTE had occurred significantly earlier in females (median age [m] 26 years, range 17-49) than in males (m = 38 years, range 21-82) (P = 0.01). 12 females (80%) had taken oral contraceptives (OC, oestrogen content 0.02-0.1 mg) for 6-150 months prior to thrombosis. Further triggering conditions in females were hormone replacement (n = 1) and pregnancy (n = 2). In 8/10 males the first VTE had occurred spontaneously - in two after surgery, The sites of VTE were deep vein thrombosis, pulmonary embolism, caval vein thrombosis and superficial thrombophlebitis.From our data we conclude that OC medication is the most important precipitating factor for VTE in females with homozygous FV Leiden.
|Title:||Oral contraceptives enhance the risk of clinical manifestation of venous thrombosis at a young age in females homozygous for factor V Leiden|
|Keywords:||thrombophilia, factor V Leiden, APC resistance, oral contraceptives, venous thromboembolism|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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