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Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR.

Cukier, CD; Ramos, A; (2011) Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR. Eur Biophys J , 40 (12) pp. 1317-1325. 10.1007/s00249-011-0698-z.

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Abstract

Here we review the role played by transient interactions between multi-functional proteins and their RNA targets in the regulation of mRNA metabolism, and we describe the important function of NMR spectroscopy in the study of these systems. We place emphasis on a general approach for the study of different features of modular multi-domain recognition that uses well-established NMR techniques and that has provided important advances in the general understanding of post-transcriptional regulation.

Type: Article
Title: Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR.
Location: Germany
DOI: 10.1007/s00249-011-0698-z
Keywords: Magnetic Resonance Spectroscopy, Models, Molecular, Protein Structure, Tertiary, RNA, RNA Processing, Post-Transcriptional, RNA, Messenger, RNA-Binding Proteins
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1418618
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