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Functional and molecular insights into KSRP function in mRNA decay.

Briata, P; Chen, C-Y; Ramos, A; Gherzi, R; (2013) Functional and molecular insights into KSRP function in mRNA decay. Biochim Biophys Acta , 1829 (6-7) pp. 689-694. 10.1016/j.bbagrm.2012.11.003.

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Abstract

KSRP is a single strand nucleic acid binding protein that controls gene expression at multiple levels. In this review we focus on the recent molecular, cellular, and structural insights into the mRNA decay promoting function of KSRP. We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms.

Type: Article
Title: Functional and molecular insights into KSRP function in mRNA decay.
Location: Netherlands
DOI: 10.1016/j.bbagrm.2012.11.003
Keywords: Binding Sites, Cell Line, Gene Expression Regulation, Humans, MicroRNAs, RNA Stability, RNA, Messenger, RNA-Binding Proteins, Trans-Activators
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1418480
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