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Somites without a clock

Dias, AS; de Almeida, I; Belmonte, JM; Glazier, JA; Stern, CD; (2014) Somites without a clock. Science , 343 (6172) pp. 791-795. 10.1126/science.1247575. Green open access

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Abstract

The formation of body segments (somites) in vertebrate embryos is accompanied by molecular oscillations ("segmentation clock"). Interaction of this with a wave travelling along the body axis (the "clock-and-wavefront model") is generally believed to control somite number, size and axial identity. Here, we show that a clock-and-wavefront is unnecessary for somite formation. Non-somite mesoderm treated with Noggin generates many somites that form simultaneously, without cyclic expression of Notch-pathway genes, yet have normal size, shape and fate. These somites have axial identity: the Hox-code is fixed independently of somite fate. However they are not subdivided into rostral and caudal halves, necessary for neural segmentation. We propose that somites are self-organizing structures whose size and shape is controlled by local cell-cell interactions.

Type: Article
Title: Somites without a clock
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.1247575
Publisher version: http://dx.doi.org/10.1126/science.1247575
Language: English
Additional information: This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on Vol. 343 no. 6172 14 February 2014, DOI: http://dx.doi.org/10.1126/science.1247575.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1418047
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