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Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health.

Kotiadis, VN; Duchen, MR; Osellame, LD; (2014) Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health. Biochim Biophys Acta , 1840 (4) pp. 1254-1265. 10.1016/j.bbagen.2013.10.041. Green open access

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Abstract

The maintenance of cell metabolism and homeostasis are fundamental characteristics of living organisms. In eukaryotes, mitochondria are the cornerstone of these life supporting processes, playing leading roles in a host of core cellular functions, including energy transduction, metabolic and calcium signalling, and supporting roles in a number of biosynthetic pathways. The possession of a discrete mitochondrial genome dictates that the maintenance of mitochondrial 'fitness' requires quality control mechanisms which involve close communication with the nucleus.

Type: Article
Title: Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbagen.2013.10.041
Publisher version: http://dx.doi.org/10.1016/j.bbagen.2013.10.041
Additional information: © 2013 The Authors. Published by Elsevier B.V. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Antioxidant Defence, Mitochondria, Mitophagy, Protein Homeostasis, Quality Control, Retrograde Signalling
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1417548
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