Widschwendter, M and Daxenbichler, G and Marth, C and Dapunt, O (1994) [Interaction of interferon with retinoic acid]. Gynakol Geburtshilfliche Rundsch , 34 (3) 168 - 170.
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Lippman and coworkers recently reported striking response rates achieved in patients with cervical cancer using a combined treatment with 13-cis-retinoic acid and interferon-alpha. In vitro studies demonstrated a synergistic amplification of proliferation inhibition by retinoids and interferon in malignant cells. Comparing all-trans- with 9-cis-retinoic acid, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. Combination of retinoic acid with interferon-gamma increased the down-regulation of specific binding sites of interferon-gamma. Expression of MHC class II antigens induced by interferon-gamma was not further enhanced by retinoic acid. These results indicate that interferon seems to modulate the retinoic acid system.
|Title:||[Interaction of interferon with retinoic acid].|
|Keywords:||Breast Neoplasms, Cell Division, Cell Line, Cell Survival, Drug Synergism, Female, Humans, Interferon-gamma, Tretinoin, Tumor Cells, Cultured|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Women's Health > Women's Cancer|
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