UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

Esteller, M; Fraga, MF; Guo, M; Garcia-Foncillas, J; Hedenfalk, I; Godwin, AK; Trojan, J; ... Herman, JG; + view all (2001) DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. HUM MOL GENET , 10 (26) pp. 3001-3007.

Full text not available from this repository.

Abstract

Cancer cells have aberrant patterns of DNA methylation including hypermethylation of gene promoter CpG islands and global demethylation of the genome. Genes that cause familial cancer, as well as other genes, can be silenced by promoter hypermethylation in sporadic tumors, but the methylation of these genes in tumors from kindreds with inherited cancer syndromes has not been well characterized. Here, we examine CpG island methylation of 10 genes (hMLH1, BRCA1, APC, LKB1, CDH1, p16(INK4a), p14(ARF), MGMT, GSTP1 and RARbeta2) and 5-methylcytosine DNA content, in inherited (n = 342) and non-inherited (n = 215) breast and colorectal cancers. Our results show that singly retained alleles of germline mutated genes are never hypermethylated in inherited tumors. However, this epigenetic change is a frequent second "hit", associated with the wild-type copy of these genes in inherited tumors where both alleles are retained. Global hypomethylation was similar between sporadic and hereditary cases, but distinct differences existed in patterns of methylation at non-familial genes. This study demonstrates that hereditary cancers "mimic" the DNA methylation patterns present in the sporadic tumors

Type: Article
Title: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis
Additional information: DA - 20011225ISSN: - 0964-6906 (Print)LA - engPT - Journal ArticleSB - IM
Keywords: CANCER, DNA, DNA Methylation, Human, OnCite, Breast, Breast Neoplasms, Colonic Neoplasms, CpG Islands, Genes, Tumor Suppressor, Genetic Predisposition to Disease, genetics, Humans, metabolism, Mutation, Neoplastic Syndromes, Hereditary, Oncogenes, physiopathology, Promoter Regions (Genetics), Syndrome
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
URI: http://discovery.ucl.ac.uk/id/eprint/141709
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item