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CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?

Church, AJ; Dale, RC; Cardoso, F; Candler, PM; Chapman, MD; Allen, ML; Klein, NJ; ... Giovannoni, G; + view all (2003) CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? J NEUROIMMUNOL , 136 (1-2) 149 - 153. 10.1016/S0165-5728(03)00012-2.

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Abstract

Previous investigations have suggested that Sydenham's chorea (SC) may be an autoantibody mediated disorder. We examined this autoimmune hypothesis by measuring Th1 (IFN-gamma, IL-12) and Th2 (IL-4, IL-10) cytokines, oligoclonal bands (OCB) and anti-basal ganglia antibodies (ABGA). CSF IL-4 was elevated in 31% of acute SC and 50% of persistent SC. CSF IL-10 was also elevated in 31% of acute SC but 0% of persistent SC. CSF IFN-gamma was undetectable in all patients. Serums IL-4, IL-10 and IL-12 were elevated in acute compared to persistent SC. OCB were found in 46% of acute SC, ABGA were in 93% of acute SC and 50% of persistent SC was of IgG(1) and IgG(3) subclass. These findings support an autoantibody pathogenesis. (C) 2003 Elsevier Science B.V. All rights reserved.

Type: Article
Title: CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?
DOI: 10.1016/S0165-5728(03)00012-2
Keywords: Sydenham's chorea, cytokines, IL-4, anti-basal ganglia antibodies, oligoclonal bands, ANTINEURONAL ANTIBODIES, GANGLIA ANTIBODIES, RHEUMATIC-FEVER, DISORDERS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/141593
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