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Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems

Bentley, JP; Asselbergs, FW; Coffey, CS; Hebert, PR; Moore, JH; Hillege, HL; van Gilst, WH; (2010) Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems. PLoS One , 5 (9) , Article e12757. 10.1371/journal.pone.0012757. Green open access

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Abstract

Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin-angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we extend this finding by exploring the effects of polymorphisms in genes from these systems on incident cardiovascular disease, explicitly examining two-way interactions in a large population-based study.

Type: Article
Title: Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0012757
Publisher version: http://dx.doi.org/10.1371/journal.pone.0012757
Language: English
Additional information: © 2010 Bentley et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2939877
Keywords: Adult, Aged, Bradykinin, Cardiovascular Diseases, European Continental Ancestry Group, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Netherlands, Polymorphism, Genetic, Renin-Angiotensin System, Risk Factors, Tissue Plasminogen Activator
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
URI: https://discovery.ucl.ac.uk/id/eprint/1414411
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