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Engineered voltage-responsive nanopores

Siwy, ZS; Howorka, S; (2010) Engineered voltage-responsive nanopores. CHEM SOC REV , 39 (3) 1115 - 1132. 10.1039/b909105j.

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Abstract

The creation of synthetic devices that mimic functionality of biological systems is a task of fundamental importance for the future development of bio- and nanotechnology and also an ultimate test of our understanding of the biological systems. Among a plethora of bio- inspired devices, designed nanopores and nanochannels with an embedded functionality are of particular interest because of their potential applications in nanofluidic electronics, biosensing, separation, synthetic biology, and single-molecule manipulation. In this respect, nanopores with built-in stimulus-responsive properties are of special benefit. A transmembrane potential is a particularly useful stimulus as it is non-invasive, tunable, and can act over a short time scale. This critical review considers engineered solid-state and protein nanopores with voltage-responsive properties. The engineered systems show nonlinear current-voltage curves, and/or voltage-dependent switching between discrete conductance states (141 references).

Type:Article
Title:Engineered voltage-responsive nanopores
DOI:10.1039/b909105j
Keywords:DNA HAIRPIN MOLECULES, ION-CURRENT RECTIFICATION, SINGLE-NUCLEOTIDE RESOLUTION, SYNTHETIC CONICAL NANOPORES, SEQUENCE-SPECIFIC DETECTION, TUNABLE NANOFLUIDIC DIODE, PROTEIN PORE, ASYMMETRIC NANOPORES, NANOTUBULE MEMBRANES, TRANSPORT-PROPERTIES
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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